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The absence of long-term human data beyond 6 weeks creates uncertainty about chronic use implications

Although studies suggest all three forms are well absorbed, better retention appears to be achieved with the natural forms of vitamin B12

For patients with unusual weight (such as morbid obesity), it may be helpful to check a phenobarbital level 2 hours after the initial loading dose (to confirm an adequate level was achieved and to calculate V D )

At this point, you can tolerate a lot more NAD+ per session, and have high enough NAD levels to go longer between sessions

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings